Sisebenzisa iikuki ukuphucula amava akho.Ngokuqhubeka ukhangela le sayithi uyavuma ukusebenzisa iikuki.Ingcaciso eyongezelelekileyo.
Uphononongo olutsha olupapashwe kwijenali yeNdalo ngo-Matshi ka-2020 inika ingxelo ngeprotheyini yothutho ekhethekileyo efumaneka kwibhaktheriya iMycobacterium tuberculosis.Ngokungafaniyo nabanye abathuthi, le proteni inkulu ye-transmembrane vesicle inceda ukuthwala iimolekyuli ze-hydrophilic, ngakumbi ivithamin B12 okanye i-cobalamin, kwiinwebu zeseli.
Uphando lusekelwe ekusebenziseni i-cryo-electron microscopy ukufumana imifanekiso ye-transporters.I-tuberculosis yinto epheleleyo ephilayo kuba inabo bonke oomatshini bofuzo abayimfuneko ukuvelisa i-cobalamin kwiiseli zayo.Nangona kunjalo, kufuneka ifumane iivithamini ezivela ngaphandle ukuze iphumelele ukwahlukana kweeseli.
Ukufezekisa oku, isebenzisa i-vitamin B12 transporter, enye yentsapho enkulu ye-ATP-binding cassette (ABC) abathuthi.Ezi proteni zisebenzisa amandla ekhemikhali agcinwe kwiimolekyuli ze-ATP ukuthwala i-substrate molecules kwi-cell membranes.Aba bathuthi nabo babandakanyeka ukuthuthwa kweepeptides ezifana ne-bleomycin, ethintela ukukhula kwe-microorganisms.Le yinto enomdla, utsho umphandi u-Dirk Slotboom, othi iimolekyuli ezimbini ezihluke kakhulu azifane zithwalwe ngumthuthi omnye.
Oku kubangele ukuba uphononongo lwangoku luphonononge ubume bale proteni ikhethekileyo.”'Ibiyinkqubo ende, kodwa saphela siyiqhekeza sisebenzisa i-cryo-electron microscopy,'” utshilo uSlotboom. Iziphumo zazimangalisa: Iprotheni iqulethe into enokuthi ichazwe njenge-gigantic, umngxuma omkhulu ozaliswe ngamanzi anyuswe kwi-membrane yeseli Ububanzi obupheleleyo, umthamo yi-7,700 cubic angstroms - ezininzi njengeemolekyuli ezisixhenxe ze-cobalamin, ngokutsho kwabaphandi. .
Umsebenzi womthuthi ngokwawo ubonakala ulula: zikhuphe nje kwaye ubeke yonke into emanzini. Yiyo loo nto isifaniso se-sluice.”Ungenisa amanzi nayo yonke into ekuwo,” uSlotboom uhlabela mgama ecacisa. Oku kunokuba yindlela yokuthutha iivithamini kunye ne-antibiotic peptides ngexesha elifanayo, nangona izakhiwo zabo zihluke kakhulu.
Izakhono zothutho ezingakhethiyo nazo zinezithintelo zazo, eyona nto ibonakalayo ingasebenzi kakuhle.Nangona kunjalo, oku akuyona ingxaki kule meko, i-Bacillus idinga kuphela ukuthatha inani eliqingqiweyo leemolekyuli ze-cobalamin ukugqiba umjikelezo wayo wokuzala ohlala malunga. iiyure ezingama-24.
Abaphandi bamangaliswa ngumahluko phakathi kwesi sithuthi kunye nawuphi na omnye umthuthi owaziwayo wesiqhelo.Bathi: "Itshintsha indlela esijonga ngayo i-bacterial physiology. Kukho ubungqina obunamandla bokuba ezinye iintlobo zeebhaktiriya zinenkqubo efanayo, nto leyo ethetha ukuba zifumana iimolekyuli ngokuzenzekela kwindawo engqongileyo.”
Ngakolunye uhlangothi, abaphandi banomdla kukuba kunokwenzeka ukuba iiseli zomntu zinokuba neendlela ezifanayo kakhulu zokuhambisa izinto ezifana ne-cobalamin. kwaye ivumela i-vitamin B12 ukuba yenze i-complex kunye nayo.I-complex ithathwa ngamaseli e-epithelial.
Olu bunzima ekugqibeleni luhlala kwii-lysosomes ngaphakathi kweeseli ze-epithelial.I-Lysosome "ziingxowa zokuzibulala" ezizaliswe ngama-enzymes anamandla.Apha, i-intrinsic factor idiliziwe kwaye i-B12 ikhutshwe kwi-lysosome kwiseli.Apha, ekugqibeleni ibandakanyeka kwi-metabolism yeeseli. . "Ndirhanela kakhulu ukuba umthuthi ofanayo nalowo ubandakanyekayo," utshilo uSlotboom.
Oosonzululwazi bacinga ukuba bangakwazi ukuvuselela umsebenzi we-cobalamin-bleomycin transporter ukunceda ukunyanga isifo sephepha.Bathi, "'Ukuba sinokuvuselela umsebenzi wesi sithuthi, kusenokwenzeka ukwazisa amayeza okubulala iintsholongwane ngokufanelekileyo kwaye ngaloo ndlela sibulale ezi zinto. iiseli ngokulula ngakumbi. Nangona kunjalo, siye saqonda ukuba oku kusenokungabi lula, njengoko iintsholongwane zisebenzisa iindlela ezisebenzayo zokuthintela amayeza okubulala iintsholongwane.”
Ukwenza oku, izazinzulu zihlalutya ngokulandelayo indlela umthuthi osebenza ngayo.Ingcamango yangoku kukuba "ngaphakathi kweseli, ii-floodgates zichithwa ngokubopha kunye ne-ATP ye-hydrolyzing. Kodwa asazi ukuba ivuleka njani ngaphandle ukuze kungene iimolekyuli ezintsha.”
Abathuthi beDimeric baquka iziqingatha ezibini.Ezi zibonakala ziphumela ngaphandle kwenwebu yeseli, kwaye kunokwenzeka ukuba zivuleke ngandlel’ ithile, njengocango, ukuze zivumele imithwalo emitsha ingene kwiseli.Izazinzulu zazifuna ukubona ukuba ziyakwazi na. ngandlela thile ivuselela le nkqubo yokuvula okanye yokukhulula, ngaloo ndlela inyusa ukungena kwamayeza okubulala iintsholongwane.
Iireferensi: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, kunye no-DJ Slotboom: Abathuthi be-Mycobacterial ABC balamla ukuthathwa kweekhompawundi ze-hydrophilic.Indalo, ngoMatshi 26, 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Tags: antibiotics, iiseli B, ibhaktheriya, iiseli, ulwahlulo lweeseli, inwebu zeseli, ii-electron, electron microscopy, genetics, ilabhoratri, lysosomes, inwebu, imetabolism, microscopy, iimolekyuli, peptides, physiology, iiproteni, isisu, iiseli T, isifo sephepha, ivithamin B12, ivithamin
UGqr. Liji Thomas nguGqirha wokuBelekisa kunye noGqirha wamaGynecologist owaphumelela kwiKholeji yezoNyango kaRhulumente, kwiYunivesithi yaseCalicut, eKerala ngo-2001. ULiji wasebenza njengomcebisi osisigxina kwizifundo zokubelekisa kunye ne-gynecology kwisibhedlele sabucala iminyaka eliqela emva kokuphumelela. Uye wabonisana namakhulu ezigulana ezijongene nemiba enxulumene nokukhulelwa kunye nokungabikho komntwana, kwaye ujonge ukuhanjiswa kwe-2,000, ehlala ezama ukuhanjiswa okuqhelekileyo kunotyando.
Thomas, Li Ji.(24 Matshi 2020) .Izazinzulu ziye zafumanisa ukuba iibhaktheriya zesifo sephepha zihambisa iivithamini kwiiseli.Iindaba-Zonyango.Ifunyenwe nge-18 kaMeyi 2022 ukusuka https://www.news-medical.net/news/20200324/Scientists-discover -i-tuberculosis-bacterium-channels-vitamins-into-the-cell.aspx.
Thomas, Li Ji.”Izazinzulu zifumanisa ukuba iintsholongwane zesifo sephepha zihambisa iivithamini kwiiseli”.Iindaba-zoNyango.May 18, 2022..
Thomas, Li Ji.”Izazinzulu zifumanisa ukuba iintsholongwane zesifo sephepha zihambisa iivithamin kwiiseli”.Iindaba-Zonyango.https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into -the-cell.aspx.(Ifikeleleke nge-18 kaMeyi 2022).
Thomas, Li Ji.2020. Izazinzulu zifumanisa iMycobacterium tuberculosis ihambisa iivithamini kwiiseli.News-Medical, ijongwe nge-18 kaMeyi, 2022, https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into-the -iseli.aspx.
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Ixesha lokuposa: May-18-2022
