Hoʻohana mākou i nā kuki e hoʻonui i kou ʻike. Ma ka hoʻomau ʻana i ka nānā ʻana i kēia pūnaewele e ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki. ʻIke hou aku.
ʻO kahi noiʻi hou i paʻi ʻia ma ka puke pai Nature ma Malaki 2020 hōʻike e pili ana i kahi protein transporter kūʻokoʻa i loaʻa i loko o ka bacteria Mycobacterium tuberculosis. ʻAʻole like me nā transporters ʻē aʻe, kōkua kēia ʻano protein transmembrane vesicle nui i ka lawe ʻana i nā molekala hydrophilic, ʻoi aku ka vitamin B12 a i ʻole cobalamin, ma waena o nā membrane cell.
Hoʻokumu ʻia ka noiʻi ma ka hoʻohana ʻana i ka microscopy cryo-electron no ka loaʻa ʻana o nā kiʻi o nā mea lawe.
No ka hoʻokō ʻana i kēia, hoʻohana ʻo ia i kahi transporter vitamin B12, kekahi o ka ʻohana nui o nā mea lawe cassette paʻa ATP (ABC). ʻO ka lawe ʻana i nā peptides e like me bleomycin, ka mea e kāohi ai i ka ulu ʻana o nā microorganisms.
ʻO kēia ka mea i hoʻoikaika i ka noiʻi o kēia manawa e nānā i ke ʻano o kēia protein kūʻokoʻa. He mea kupanaha nā hopena: Aia i loko o ka protein ka mea hiki ke wehewehe ʻia he gigantic, kahi lua nui i hoʻopiha ʻia i ka wai i hoʻonui ʻia i loko o ka membrane cell ʻO ka laulā holoʻokoʻa, ʻo ka hiki ke 7,700 cubic angstroms - e like me ʻehiku mau molela cobalamin, e like me ka poʻe noiʻi. .
He mea maʻalahi ka hana a ka mea lawe: e hoʻokaʻawale iā ia iho a waiho i nā mea a pau i loko o ka wai. ʻO kēia paha ke ala e lawe ai i nā huaora a me nā peptides antibiotic i ka manawa like, ʻoiai he ʻokoʻa loa ko lākou mau hale.
Loaʻa i ka hiki ʻole o ka lawe ʻana ke koho i kā lākou drawbacks, ʻo ka mea maopopo loa ʻo ia ka inefficiency. Akā naʻe, ʻaʻole kēia he pilikia i kēia hihia, pono wale ka Bacillus e lawe i kahi helu palena o nā molela cobalamin e hoʻopau i kāna pōʻai hānau e mau ana ma kahi o 24 hola.
Pīhoihoi ka poʻe noiʻi i ka ʻokoʻa ma waena o kēia transporter a me nā transporter maʻamau ʻē aʻe i ʻike ʻia. Aia nā hōʻailona ikaika e loaʻa i nā ʻano bacteria ʻē aʻe nā ʻōnaehana like, ʻo ia hoʻi, loaʻa iā lākou nā molekole mai ke kaiapuni.
Ma ka ʻaoʻao ʻē aʻe, pīhoihoi ka poʻe noiʻi i ka hiki ke loaʻa i nā pūnaewele kanaka ke ʻano like loa no ka lawe ʻana i nā mea e like me cobalamin. Hoʻopili mua kēia huaora i kahi peptide gastric i kapa ʻia intrinsic factor. a hiki i ka huaora B12 ke hana i mea paʻakikī me ia.
Hoʻopili kēia paʻakikī i nā lysosomes i loko o nā pūnaewele epithelial. ʻO nā lysosomes nā "ʻeke pepehi kanaka" i hoʻopiha ʻia me nā enzymes ikaika. Maanei, ua wāwahi ʻia ka intrinsic factor a hoʻokuʻu ʻia ka B12 mai ka lysosome i loko o ke kelepona. "Ke manaʻo nui nei au e pili ana kahi transporter nonspecific like," wahi a Slotboom.
Manaʻo nō hoʻi nā kānaka ʻepekema hiki iā lākou ke hoʻoulu i ka hana o ka cobalamin-bleomycin transporter e kōkua i ka mālama ʻana i ka maʻi maʻi. maʻalahi nā pūnaewele. Eia nō naʻe, ua ʻike mākou ʻaʻole maʻalahi kēia, no ka mea, hoʻohana ka bacteria i nā hoʻolālā maikaʻi e mālama i nā lāʻau antibiotic.
No ka hana ʻana i kēia, e ʻimi hou ana nā ʻepekema i ke ʻano o ka hana ʻana o ka mea lawe. Akā ʻaʻole maopopo iā mākou pehea ka wehe ʻana i waho e hoʻokuʻu i nā molekala hou.
ʻO nā mea lawe dimeric he ʻelua hapa. ʻIke ʻia kēia mau mea i waho o ka membrane cell, a hiki ke wehe ʻia ma kekahi ala, e like me ka puka, e ʻae i ka ukana hou i loko o ke keʻena. Ua makemake nā ʻepekema e ʻike inā hiki iā lākou e hoʻoulu i kēia kaʻina hana wehe a wehe paha, ma laila e hoʻonui ai i ke komo ʻana o nā lāʻau antibiotic.
Nānā: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, a me DJ Slotboom: Mycobacterial ABC transporters mediate the uptake of hydrophilic compounds.Nature, March 26, 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Nā huaʻōlelo: nā lāʻau antibiotic, B cell, bacteria, cell, cell division, cell membranes, electrons, electron microscopy, genetics, laboratory, lysosomes, membranes, metabolism, microscopy, molecules, peptides, physiology, proteins, ʻōpū, T cell, tuberculosis , vitamina B12, ka huaora
ʻO Kauka Liji Thomas he Obstetrician a Gynecologist i puka i ke kula kiʻekiʻe mai ke Kulanui Lapaʻau o ke Aupuni, ke Kulanui ʻo Calicut, Kerala ma 2001. Ua hana ʻo Liji ma ke ʻano he kūkākūkā piha i ka obstetrics a me ka gynecology ma kahi haukapila pilikino no kekahi mau makahiki ma hope o ka puka ʻana. Ua kūkākūkā ʻo ia i nā haneli o nā mea maʻi e kū nei i nā pilikia pili i ka hāpai ʻana a me ka infertility, a ua mālama ʻo ia ma luna o 2,000 mau hoʻopuka, e hoʻoikaika mau ana no ka hānau maʻamau ma mua o ke ʻoki.
Thomas, Li Ji.(24 Malaki 2020). Ua ʻike ka poʻe ʻepekema e lawe ana ka bacteria maʻi maʻi i nā huaora i loko o nā cell. Nūhou - Lapaʻau. Loaʻa ʻia ma 18 Mei 2022 mai https://www.news-medical.net/news/20200324/Scientists-discover -maʻi-bacterium-channels-vitamina-i-ke-kele.aspx.
Thomas, Li Ji. "Ua ʻike nā kānaka ʻepekema e lawe ana ka bacteria maʻi maʻi i nā huaora i loko o nā cell". Nūhou - Lapaʻau. Mei 18, 2022.
Thomas, Li Ji. "Ua ʻike nā ʻepekema ʻo ka maʻi maʻi maʻi maʻi e lawe i nā huaora i loko o nā cell". Nūhou - Lapaʻau.https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into -the-cell.aspx.(Loaʻa iā 18 Mei 2022).
Thomas, Li Ji.2020. Ua ʻike nā kānaka ʻepekema ʻo Mycobacterium tuberculosis e lawe ana i nā huaora i loko o nā cell.News-Medical, nānā ʻia ma Mei 18, 2022, https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into-the -cell.aspx.
Ma kēia nīnauele, kamaʻilio mākou me Kauka Damini Dey o Cedars-Sinai Medical Center e pili ana i kā lākou noiʻi hou loa e pili ana i ka hoʻohana ʻana iā AI e wānana i ka hōʻeha o ka naʻau.
Ma kēia nīnauele, kamaʻilio ʻo News-Medical iā Kauka Laurence Orbuch e pili ana i ka nele o ka ʻike ma hope o nā kūlana gynecological e like me endometriosis a pehea e hoʻololi ai.
Ma kēia nīnauele, kamaʻilio mākou me ka Luna Lapaʻau Nui o CMR Surgical, ʻo Mark Slack, e pili ana i kā lākou lopako hōʻeuʻeu hou, ʻo ka Versius.
Hāʻawi ʻo News-Medical.Net i kēia lawelawe ʻike olakino e like me kēia mau ʻōlelo a me nā ʻano.
Ka manawa hoʻouna: Mei-18-2022
