Dukoresha kuki kugirango tuzamure uburambe.Mu gukomeza gushakisha kururu rubuga wemera gukoresha kuki. Andi makuru.
Ubushakashatsi bushya bwasohotse mu kinyamakuru Nature muri Werurwe 2020 butanga raporo kuri poroteyine idasanzwe itwara abantu iboneka muri bagiteri Mycobacterium tuberculose. Bitandukanye n’abandi batwara abantu, iyi proteine nini ya transembrane vesicle ifasha gutwara molekile ya hydrophilique, cyane cyane vitamine B12 cyangwa cobalamine, hejuru ya selile.
Ubushakashatsi bushingiye ku gukoresha microscopi ya cryo-electron kugirango ibone amashusho yabatwara.Igituntu ni ikinyabuzima cyuzuye kuko gifite imashini zikenewe zose zikomoka kuri cobalamine mu ngirabuzimafatizo zacyo.Nyamara, igomba kwakira vitamine ziturutse hanze kugirango igabanye ingirabuzimafatizo.
Kugira ngo ibyo bigerweho, ikoresha vitamine B12 itwara abantu, umwe mu muryango munini wabatwara cassette ya ATP ihuza (ABC). Izi poroteyine zikoresha ingufu za chimique zibitswe muri molekile ya ATP kugirango zitware molekile ya substrate hejuru ya selile. Aba batwara nabo babigiramo uruhare umushakashatsi witwa Dirk Slotboom, avuga ko gutwara ibintu bya peptide nka bleomycine, bibuza ikura rya mikorobe. Ibi ni ibintu by'amatsiko, nk'uko byatangajwe n'umushakashatsi Dirk Slotboom, uvuga ko molekile ebyiri zitandukanye cyane zidakunze gutwarwa n'umuntu umwe utwara abantu.
Ibi byatumye ubushakashatsi buriho busuzuma imiterere ya poroteyine idasanzwe. "Slotboom yagize ati:" Byari inzira ndende, ariko twarangije kuyimena dukoresheje microscopi ya cryo-electron. " Ibisubizo byatangaje: Poroteyine yarimo icyashoboraga kuvugwa gusa ko ari igihangange, umwobo munini wuzuyemo amazi wagutse muri selile selile Ubugari bwose, ubushobozi ni 7.700 cubic angstroms - nka molekile zirindwi za cobalamine. .
Akazi k'abatwara ubwako gasa nkako koroheje: gusa konyine kandi ushire ibintu byose mumazi. Noneho igereranya rya sluice. "Urareka mumazi nibintu byose birimo," Slotboom akomeza abisobanura. Ubu bushobora kuba uburyo bushobora gutwara vitamine na peptide ya antibiotique icyarimwe, nubwo imiterere yabyo itandukanye cyane.
Ubushobozi bwo gutwara abantu butatoranijwe nabwo bufite aho bugarukira, ikigaragara cyane muri byo ni ukudakora neza.Nyamara, iki ntabwo arikibazo muriki kibazo, Bacillus ikeneye gufata gusa umubare muto wa molekile ya cobalamin kugirango irangize ukwezi kwayo kwimyororokere kumara. Amasaha 24.
Abashakashatsi batunguwe no gutandukanya uyu mutwara n’abandi bantu bose bazwiho gutwara abantu.Bagize icyo bavuga: “Irahindura uburyo tubona physiologiya ya bagiteri. Hariho ibimenyetso bifatika byerekana ko andi moko ya bagiteri afite sisitemu imwe, bivuze ko ibona molekile ku buryo butemewe n'ibidukikije. ”
Ku rundi ruhande, abashakashatsi bashishikajwe no kuba bishoboka ko ingirabuzimafatizo z'abantu zishobora no kuba zifite uburyo busa cyane bwo gutwara ibintu nka cobalamin. Iyi vitamine ibanza guhuza peptide yo mu gifu yitwa intrinsic factor.Iyi peptide ikomoka mu ngirabuzimafatizo zihariye zo mu gifu ziri mu gifu. kandi yemerera vitamine B12 gukora complex hamwe nayo.Ikigo noneho gifatwa na selile epithelial selile.
Uru ruganda amaherezo rutura muri lysosomes muri selitile epithelia.Lysosomes ni "imifuka yo kwiyahura" yuzuyemo imisemburo ikomeye. Hano, ibintu byimbere byacitse kandi B12 irekurwa ikava muri lysosome ikajya mu kagari. Hano, amaherezo igira uruhare muri metabolism ya selile. . "Ndakeka cyane ko umutwara nk'uwo udafite akamaro arimo." Slotboom.
Abahanga batekereza kandi ko bashobora kuzamura ibikorwa byabatwara cobalamin-bleomycine kugirango bafashe kuvura igituntu.Bagize bati: "'Niba dushobora gushimangira ibikorwa byu mutwara, birashoboka ko twinjiza antibiyotike neza bityo tukica abo selile byoroshye. Icyakora, twabonye ko ibyo bidashobora kuba byoroshye, kubera ko bagiteri ikoresha ingamba zifatika zo kwirinda antibiyotike. ”
Kugirango ukore ibi, abahanga bakurikiraho basesengura uko abatwara ibintu bakora. Igitekerezo kiriho ni uko "imbere mu kagari, imyuzure iba irimo ubusa no guhambira hamwe na hydrolyzing ATP. Ariko ntituzi uko ikingura hanze kugirango ireke molekile nshya. ”
Abatwara Dimeric bagizwe n'ibice bibiri.Ibyo bigaragara ko bisohoka hanze ya selile, kandi birashoboka ko bafungura muburyo bumwe, nk'urugi, kugirango imizigo mishya yinjire muri selire.Abahanga bifuzaga kureba niba babishoboye. hari ukuntu utera iyi nzira yo gufungura cyangwa kurekura, bityo ukongera kwinjiza antibiyotike.
Reba: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, na DJ Slotboom: Abatwara Mycobacterial ABC bahuza no gufata imiti ya hydrophilique. Kamere, 26 Werurwe 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Etiquetas: antibiyotike, selile B, bagiteri, selile, kugabana selile, membrane selile, electron, microscopi electron, genetics, laboratoire, lysosomes, membrane, metabolism, microscopi, molekile, peptide, physiologiya, proteyine, igifu, T selile, igituntu, vitamine. B12, vitamine
Dr. Liji Thomas ni Umuganga w’ububyaza n’umugore warangije mu ishuri rikuru ry’ubuvuzi rya Leta, muri kaminuza ya Calicut, muri Kerala mu 2001. Liji yakoraga nk'umujyanama w'igihe cyose mu bijyanye no kubyara n'abagore mu bitaro byigenga imyaka myinshi nyuma yo guhabwa impamyabumenyi. Yagishije inama abarwayi babarirwa mu magana bahura n’ibibazo bijyanye no gutwita no kutabyara, kandi yagenzuye kubyara birenga 2000, ahora aharanira kubyara bisanzwe aho kubagwa.
Thomas, Li Ji. (24 Werurwe 2020) .Abahanga bavumbuye ko bagiteri yigituntu itwara vitamine mu ngirabuzimafatizo. Amakuru -igituntu-bacterium-imiyoboro-vitamine-muri-selile.aspx.
Thomas, Li Ji. "Abahanga bavumbuye ko bagiteri yigituntu itwara vitamine mu ngirabuzimafatizo" .Amakuru - Ubuvuzi. Ku ya 18 Gicurasi 2022 ..
Thomas, Li Ji. "Abahanga bavumbuye ko bagiteri yigituntu itwara vitamine mu ngirabuzimafatizo" .Amakuru - Ubuvuzi.https: //www.amakuru-amakuru-amakuru -akagari.aspx. (Byemewe 18 Gicurasi 2022).
Thomas, Li Ji.2020. Abahanga bavumbuye igituntu cya Mycobacterium itwara vitamine mu ngirabuzimafatizo.Amakuru-Ubuvuzi, yarebwaga ku ya 18 Gicurasi 2022, https://www.amakuru-amakuru-yamakuru -cell.aspx.
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Amakuru-Ubuvuzi.Net itanga iyi serivise yamakuru yubuvuzi ukurikije aya mabwiriza. Nyamuneka menya ko amakuru yubuvuzi kururu rubuga agamije gushyigikira no kudasimbuza umubano wumurwayi-umuganga / umuganga ninama zubuvuzi bashobora gutanga.
Igihe cyo kohereza: Gicurasi-18-2022
