Isu tinoshandisa makuki kuwedzera ruzivo rwako.Nekuramba uchitsvaga saiti ino unobvuma kushandisa kwedu makuki.Rumwe ruzivo.
Chidzidzo chitsva chakaburitswa mujenari Nature muna Kurume 2020 chinoshuma nezve yakasarudzika puroteni inotakura inowanikwa mubhakitiriya Mycobacterium tuberculosis.Kusiyana nemamwe mafambisi, iyi hombe transmembrane vesicle protein inobatsira kutakura ma hydrophilic mamorekuru, kunyanya vhitamini B12 kana cobalamin, pamasero membranes.
Tsvakurudzo yakavakirwa pakushandisa cryo-electron microscopy kuwana mifananidzo yevatakuri.Tuberculosis imhuka yakakwana nokuti ine zvose zvinodiwa genetic machines kuti ibudise cobalamin mumasero ayo.Zvisinei, inofanira kugamuchira mavhitamini kubva kunze kuti ibudirire kupatsanurwa kwesero.
Kuti iite izvi, inoshandisa mutakuri wevhitamini B12, imwe yemhuri huru yevatakuri veATP-binding cassette (ABC). Mapuroteni aya anoshandisa simba remakemikari rinochengetwa mumamolekemu eATP kutakura mamorekuru e substrate pamasero emasero.Vatakuri ava vanobatanidzwawo kutakurwa kwemapeptides akadai sebleomycin, iyo inotadzisa kukura kweutachiona.Ichi chinhu chinoda kuziva, anodaro muongorori Dirk Slotboom, anoti mamorekuru maviri akasiyana-siyana haawanzotakurwa nemutakuri mumwe chete.
Izvi zvakaita kuti ongororo yazvino iongorore chimiro cheprotein iyi yakasarudzika. ”'Yakanga iri muitiro wakareba, asi takazopedzisira tava kutsemura tichishandisa cryo-electron microscopy,'” Slotboom akadaro. Mhedzisiro yacho yaishamisa: Protein yaingogona kutsanangurwa sehombe, gomba rakakura rakazadzwa nemvura yaienda mukati me membrane yesero Upamhi hwese, huwandu hwacho 7,700 cubic angstroms - anosvika manomwe cobalamin mamorekuru, sekureva kwevaongorori. .
Basa remutakuri pacharo rinoita serakapfava: kungozvidurura woisa zvese mumvura. Ndosaka mufananidzo wesluice."Uri kupinza mumvura nezvose zviri mairi," Slotboom anoenderera mberi achitsanangura. Izvi zvingava nzira iyo inogona kutakura mavitamini uye antibiotic peptides panguva imwe chete, kunyange zvazvo zvimiro zvavo zvakasiyana zvikuru.
Zvisizvo-zvakasarudzwa zvikwanisiro zvekutakura zvinewo zvipingamupinyi zvadzo, izvo zvinonyanya kujeka izvo zvisingakwanisi.Zvisinei, iyi haisi dambudziko munyaya iyi, Bacillus inongoda kutora nhamba shoma ye cobalamin molecules kuti ipedze kubereka kwayo kunotora nguva. 24 maawa.
Vatsvakurudzi vakashamiswa nemusiyano pakati pemutakuri uyu uye chero upi zvake anozivikanwa mutakuri wemazuva ose.Vakataura kuti: "Inoshandura nzira yatinotarisa nayo physiology yebhakitiriya. Pane zviratidzo zvakasimba zvekuti mamwe marudzi emabhakitiriya ane maitiro akafanana, zvichireva kuti anowana mamorekuru kubva kune zvakatipoteredza.
Nekune rimwe divi, vatsvakurudzi vari kushamiswa nemukana wekuti masero emunhu anogonawo kunge aine nzira dzakafanana dzekutakura zvinhu zvakaita secobalamin. Vhitamini iyi inotanga kusunga kune gastric peptide inonzi intrinsic factor.Iyi peptide inobva kune specialized parietal cells ari mudumbu. uye inobvumira vitamini B12 kuti iite yakaoma nayo.Iyo yakaoma inobva yatorwa nemasero epithelial.
Iyi yakaoma inopedzisira yagadzikana mu lysosomes mukati me epithelial cells.Lysosomes "mabhegi ekuzviuraya" akazadzwa nema enzymes ane simba.Pano, intrinsic factor inoputsika uye B12 inosunungurwa kubva kune lysosome kusvika muchitokisi.Pano, pakupedzisira inobatanidzwa mumetabolism yemasero. . "Ndinofungidzira zvakanyanya kuti mumwe mutakuri akafanana ane chekuita," Slotboom akadaro.
Vesainzi vanofungawo kuti vanogona kumutsa basa remutakuri wecobalamin-bleomycin kubatsira kurapa tibhii.Vakati, “'Dai tikakwanisa kumutsa basa remutakuri uyu, zvingakwanisika kuunza mishonga inorwisa mabhakitiriya nenzira kwayo uye nokudaro kuuraya aya masero zviri nyore. Zvisinei, takaona kuti izvi zvingasava nyore, sezvo mabhakitiriya anoshandisa nzira dzinoshanda kuti mishonga inorwisa mabhakitiriya isapinde.
Kuti aite izvi, masayendisiti anotevera kuongorora kuti mutakuri anoshanda sei. Ikozvino fungidziro ndeyekuti "mukati mesero, magedhi emvura anodururwa nekusunga uye hydrolyzing ATP. Asi isu hatizive kuti inovhurika sei kunze kuti ipinde mamorekuru matsva.
Vatakuri veDimeric vane mahafu maviri.Izvi zvinoita sekunge zvichibuda kunze kwe membrane yesero, uye zvinogoneka kuti zvinovhura neimwe nzira, senge gonhi, kubvumira mitsva mitsva kupinda muchitokisi.Masayendisiti aida kuona kana vaigona. neimwe nzira inomutsa nzira yekuvhura kana kusunungura, nekudaro kuwedzera kupinda kwemishonga inorwisa mabhakitiriya.
Mareferensi: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, uye DJ Slotboom: Mycobacterial ABC vatakuri vanopindirana nekutora kwehydrophilic compounds.Nature, Kurume 26, 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Tags: mishonga inorwisa mabhakitiriya, B masero, mabhakitiriya, masero, kupatsanurwa kwesero, masero membranes, maerekitironi, electron microscopy, genetics, rabhoritari, lysosomes, membranes, metabolism, microscopy, mamorekuru, peptides, physiology, mapuroteni, dumbu, T masero, tibhii , vhitamini B12, vitamini
Dr. Liji Thomas iObstetrician uye Gynecologist uyo akapedza kudzidza kubva kuHurumende Medical College, Calicut University, Kerala muna 2001.Liji akashanda semuongorori wenguva yakazara mune zvekudzivirira uye gynecology pachipatara chakazvimiririra kwemakore akati wandei apedza kudzidza. Akabvunza mazana evarwere vakatarisana nenyaya dzine chekuita nepamuviri uye kushaya mbereko, uye akatarisira kusununguka kwezviuru zviviri, achigara achiedza kusununguka pane kuvhiyiwa.
Thomas, Li Ji.(24 Kurume 2020).Masayendisiti akawana kuti utachiona hwetibhii hunotakura mavhitamini mumaseru.Nhau - Medical.Retrieved 18 May 2022 kubva https://www.news-medical.net/news/20200324/Scientists-discover -tuberculosis-bacterium-channels-vitamins-into-the-cell.aspx.
Thomas, Li Ji."Masayendisiti anoona kuti utachiona hwetibhii hunotakura mavhitamini mumaseru".Nhau - Medical.Chivabvu 18, 2022..
Thomas, Li Ji.” Masayendisiti anoona kuti utachiona hwetibhii hunotakura mavhitamini mumasero”.News – Medical. -the-cell.aspx.(Yakasvika 18 Chivabvu 2022).
Thomas, Li Ji.2020. Masayendisiti anoona Mycobacterium tuberculosis inotakura mavhitamini mumaseru -cell.aspx.
Mubvunzurudzo iyi, tinotaura naDr. Damini Dey weCedars-Sinai Medical Center pamusoro pekutsvakurudza kwavo kwekupedzisira kwekushandisa AI kufanotaura kurwisa kwemwoyo.
Mubvunzurudzo iyi, News-Medical inotaura naDr. Laurence Orbuch nezvekusanzwisisa kuseri kwemamiriro echikadzi senge endometriosis uye maitiro ekuchinja izvozvo.
Mubvunzurudzo iyi, tinokurukura neCMR Surgical's Chief Medical Officer, Mark Slack, nezve chizvarwa chavo chinotevera chekuvhiya robhoti, iyo Versius.
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Nguva yekutumira: May-18-2022
