Muna amfani da kukis don haɓaka ƙwarewar ku.Ta ci gaba da bincika wannan rukunin yanar gizon kun yarda da amfani da kukis.Ƙarin bayani.
Wani sabon binciken da aka buga a cikin mujallar Nature a watan Maris 2020 ya ba da rahoto game da furotin mai jigilar kayayyaki na musamman da aka samu a cikin ƙwayar ƙwayar cuta ta Mycobacterium.
Binciken ya dogara ne akan amfani da microscopy na cryo-electron don samun hotunan masu jigilar kaya.Tarin tarin fuka cikakkiyar halitta ce saboda tana da dukkanin kayan aikin kwayoyin halitta don samar da cobalamin a cikin sel. Duk da haka, dole ne ya karbi bitamin daga waje don samun nasarar rarraba kwayoyin halitta.
Don cim ma wannan, yana amfani da mai ɗaukar bitamin B12, ɗaya daga cikin babban iyali na masu jigilar kaset na ATP (ABC).Wadannan sunadaran suna amfani da makamashin sinadarai da aka adana a cikin ƙwayoyin ATP don ɗaukar kwayoyin halitta a cikin membranes tantanin halitta. safarar peptides irin su bleomycin, wanda ke hana ci gaban ƙwayoyin cuta.Wannan wani lamari ne mai ban sha'awa, in ji wani mai bincike Dirk Slotboom, wanda ya ce da wuya wasu kwayoyin halitta guda biyu daban-daban suke ɗaukar su.
Wannan ya sa binciken na yanzu ya bincika tsarin wannan furotin na musamman.” 'Yana da tsayin tsari, amma mun ƙare da fatattakar shi ta amfani da microscopy na cryo-electron,' "in ji Slotboom. Sakamakon ya kasance mai ban sha'awa: Sunadaran ya ƙunshi abin da kawai za a iya kwatanta shi a matsayin gigantic, babban rami mai cike da ruwa wanda ya shimfiɗa a cikin membrane cell Duk faɗin, ƙarfin yana da 7,700 cubic angstroms - kamar kwayoyin cobalamin guda bakwai, a cewar masu binciken. .
Aikin mai ɗaukar kaya da kansa yana da sauƙi: kawai komai kansa kuma ya sanya komai a cikin ruwa. Saboda haka kwatankwacin sluice. Wannan yana iya zama yadda zai iya jigilar bitamin da peptides na rigakafi a lokaci guda, kodayake tsarin su ya bambanta sosai.
Hanyoyin sufurin da ba zaɓaɓɓu ba suma suna da nasu illa, wanda mafi bayyanannensu shine rashin aiki.Duk da haka, wannan ba matsala ba ce a wannan yanayin, Bacillus kawai yana buƙatar ɗaukar adadin adadin ƙwayoyin cobalamin don kammala sake zagayowar haihuwa wanda ke dawwama game da shi. awa 24.
Masu binciken sun yi mamakin bambancin da ke tsakanin wannan mai jigilar kaya da duk wani mai jigilar kayayyaki na al'ada da aka sani. Sun yi sharhi: "Yana canza yadda muke kallon ilimin kwayoyin halitta. Akwai alamu masu ƙarfi cewa sauran nau'in ƙwayoyin cuta suna da tsari iri ɗaya, ma'ana suna samun ƙwayoyin cuta ba da gangan ba daga muhalli."
A gefe guda kuma, masu bincike suna sha'awar yiwuwar cewa ƙwayoyin ɗan adam na iya samun nau'ikan nau'ikan nau'ikan jigilar abubuwa kamar cobalamin. Wannan bitamin ya fara ɗaure zuwa peptide na ciki da ake kira intrinsic factor. Wannan peptide ya fito ne daga ƙwayoyin parietal na musamman a cikin rufin ciki. kuma yana ba da damar bitamin B12 don samar da hadaddun tare da shi. Rukunin epithelial yana ɗaukar hadaddun.
Wannan hadaddun daga ƙarshe ya zauna a cikin lysosomes a cikin sel epithelial. Lysosomes sune "jakunkuna na kashe kansu" cike da enzymes masu ƙarfi. Anan, abubuwan da ke cikin ciki sun rushe kuma an saki B12 daga lysosome zuwa cikin tantanin halitta. "Ina zargin cewa akwai wani nau'in jigilar kaya iri ɗaya," in ji Slotboom.
Har ila yau, masana kimiyya suna tunanin za su iya motsa aikin jigilar cobalamin-bleomycin don taimakawa wajen magance cutar tarin fuka. Sun ce, "'Idan za mu iya motsa aikin wannan jigilar, yana iya yiwuwa a gabatar da maganin rigakafi da kyau kuma ta haka ne ya kashe wadannan. Kwayoyin da sauƙi. Duk da haka, mun fahimci cewa wannan ba zai zama mai sauƙi ba, saboda ƙwayoyin cuta suna amfani da ingantattun dabaru don hana maganin rigakafi. "
Don yin wannan, masana kimiyya na gaba suna nazarin yadda mai jigilar kaya ke aiki.Tsarin halin yanzu shine "a cikin tantanin halitta, an zubar da ambaliyar ruwa ta hanyar ɗaurewa da kuma sanya ruwa ATP. Amma ba mu san yadda ake buɗewa a waje don bari a shigar da sabbin ƙwayoyin cuta ba.”
Masu jigilar Dimeric sun ƙunshi rabi biyu. Waɗannan sun bayyana suna fitowa zuwa waje na membrane na tantanin halitta, kuma yana yiwuwa su buɗe ta wata hanya, kamar kofa, don ba da damar sabbin kaya a cikin tantanin halitta. Masanan kimiyya sun so su ga ko za su iya. ko ta yaya ta motsa wannan tsari na buɗewa ko sassautawa, ta haka yana ƙara shigar da maganin rigakafi.
Nassoshi: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, da DJ Slotboom: Mycobacterial ABC masu jigilar kayayyaki suna yin sulhu da ɗaukar mahaɗan hydrophilic.Nature, Maris 26, 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Tags: maganin rigakafi, Kwayoyin B, kwayoyin cuta, Kwayoyin, cell division, cell membranes, electrons, electron microscopy, genetics, dakin gwaje-gwaje, lysosomes, membranes, metabolism, microscopy, kwayoyin, peptides, physiology, sunadarai, ciki, T Kwayoyin, tarin fuka , bitamin B12, bitamin
Dokta Liji Thomas likitan mata ne da likitan mata wanda ya sauke karatu daga Kwalejin Kiwon Lafiya ta Gwamnati, Jami'ar Calicut, Kerala a 2001. Liji ya yi aiki a matsayin mai ba da shawara na cikakken lokaci a fannin ilimin mata da mata a wani asibiti mai zaman kansa na shekaru da yawa bayan kammala karatunsa. Ta tuntubi daruruwan majinyata da ke fuskantar matsalolin da suka shafi ciki da rashin haihuwa, kuma ta kula da haihuwa sama da 2,000, a kodayaushe suna kokarin haihuwa na yau da kullun maimakon tiyata.
Thomas, Li Ji. -tuberculosis-kwayoyin-tashoshi-bitamin-zuwa-cell.aspx.
Thomas, Li Ji." Masana kimiyya sun gano cewa kwayoyin cutar tarin fuka suna jigilar bitamin zuwa cikin sel." Labarai - Likita.Mayu 18, 2022.
Thomas, Li Ji." Masana kimiyya sun gano cewa kwayoyin cutar tarin fuka suna jigilar bitamin zuwa cikin sel." Labarai - Likitanci. -the-cell.aspx.(An shiga 18 ga Mayu 2022).
Thomas, Li Ji.2020. Masana kimiyya sun gano tarin fuka na Mycobacterium yana jigilar bitamin zuwa cikin sel.News-Medical, duba Mayu 18, 2022, https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into-the -cell.aspx.
A cikin wannan hirar, muna magana da Dr. Damini Dey na Cibiyar Kiwon Lafiya ta Cedars-Sinai game da sabon binciken da suka yi kan amfani da AI don hasashen bugun zuciya.
A cikin wannan hira, News-Medical yayi magana da Dr. Laurence Orbuch game da rashin fahimta bayan yanayin gynecological kamar endometriosis da kuma yadda za a canza wannan.
A cikin wannan hirar, mun tattauna da Babban Jami'in Lafiya na CMR Surgical, Mark Slack, game da robot ɗin tiyata na gaba, Versius.
News-Medical.Net yana ba da wannan sabis ɗin bayanin likita daidai da waɗannan sharuɗɗan da sharuɗɗan. Lura cewa bayanin likita akan wannan rukunin yanar gizon an yi niyya don tallafawa kuma ba maye gurbin haɗin gwiwar likita-likita / likita ba da shawarar likita da zasu iya bayarwa.
Lokacin aikawa: Mayu-18-2022
