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Phuputso e ncha e phatlalalitsoeng koranteng ea Nature ka Hlakubele 2020 e tlaleha ka protheine e ikhethang ea sepalangoang e fumanehang ho baktheria Mycobacterium tuberculosis.Ho fapana le lipalangoang tse ling, protheine ena e kholo ea transmembrane vesicle e thusa ho jara limolek'hule tsa hydrophilic, haholo vithamine B12 kapa cobalamin, ho pholletsa le lisele tsa lisele.
Lipatlisiso li itšetlehile ka ho sebelisa microscopy ea cryo-electron ho fumana litšoantšo tsa li-transporters.Lefuba ke ntho e phelang e feletseng hobane e na le mechine eohle ea liphatsa tsa lefutso e hlokahalang ho hlahisa cobalamin liseleng tsa eona.Leha ho le joalo, e tlameha ho fumana livithamine tse tsoang ka ntle bakeng sa ho arohana ha lisele tse atlehileng.
Ho finyella sena, e sebelisa sepalangoang sa vithamine B12, e mong oa lelapa le leholo la li-transporter tsa ATP-binding cassette (ABC). ho tsamaisoa ha li-peptide tse kang bleomycin, e thibelang ho hōla ha likokoana-hloko.Ena ke ntho e makatsang, ho bolela mofuputsi Dirk Slotboom, ea reng limolek'hule tse peli tse fapaneng haholo ha se hangata li tsamaisoang ke sepalangoang se le seng.
Sena se ile sa susumelletsa phuputso ea hona joale ho hlahloba sebōpeho sa protheine ena e ikhethang. "'E ne e le ts'ebetso e telele, empa re ile ra qetella re e senya ka ho sebelisa microscopy ea cryo-electron," Slotboom o itse. Liphetho li ne li hlolla: Protheine e ne e na le se ka hlalosoang e le se seholohali, sekoti se seholo se tletseng metsi se atolositsoeng ka har'a lera la sele Bophara bohle, matla ke li-cubic angstroms tse 7,700 - hoo e ka bang limolek'hule tse supileng tsa cobalamin, ho latela bafuputsi. .
Mosebetsi oa sepalangoang ka booona o bonahala o le bonolo: ipholle feela ebe u kenya ntho e 'ngoe le e 'ngoe ka metsing. Kahoo papiso ea sluice.” U kenya metsi le tsohle tse ho ona," Slotboom o tsoela pele ho hlalosa. Ena e ka 'na ea e-ba tsela eo e ka tsamaisang livithamine le li-peptide tsa lithibela-mafu ka nako e le' ngoe, le hoja mehaho ea tsona e fapane haholo.
Bokhoni ba lipalangoang bo sa khethoeng le bona bo na le mefokolo ea bona, e hlakileng ka ho fetesisa ke ho se sebetse hantle.Leha ho le joalo, sena ha se bothata tabeng ena, Bacillus e hloka feela ho nka palo e lekanyelitsoeng ea limolek'hule tsa cobalamin ho phethela potoloho ea eona ea ho ikatisa e nkang hoo e ka bang. Lihora tse 24.
Bafuputsi ba ile ba makatsoa ke phapang pakeng tsa sepalangoang sena le sepalangoang leha e le sefe se tsebahalang se tloaelehileng.Ba ile ba re: “E fetola tsela eo re talimang physiology ea baktheria. Ho na le matšoao a matla a hore mefuta e meng ea libaktheria e na le litsamaiso tse tšoanang, ho bolelang hore li fumana limolek’hule ka tsietsi tikolohong.”
Ka lehlakoreng le leng, bafuputsi ba hlolloa ke monyetla oa hore lisele tsa motho le tsona li ka ba le mekhoa e tšoanang haholo ea ho tsamaisa lintho tse kang cobalamin.Vithamine ena e qala ho tlama peptide ea gastric e bitsoang intrinsic factor.Peptide ena e tsoa liseleng tse khethehileng tsa parietal ka har'a lesela la mpa. 'me e lumella vithamine B12 hore e thehe ntho e rarahaneng le eona.E rarahaneng e ntan'o nkoa ke lisele tsa epithelial.
Qetello ena e rarahaneng e lula ka har'a li-lysosomes ka har'a lisele tsa epithelial. Li-lysosomes ke "mekotla ea ho ipolaea" e tletseng li-enzyme tse matla. Mona, ntho e ka hare e senyeha 'me B12 e lokolloa ho tloha lysosome ho kena ka seleng.Mona, qetellong e ameha metabolism ea lisele. . "Ke belaela haholo hore ho na le sepalangoang se tšoanang se sa tobang taba," ho boletse Slotboom.
Bo-rasaense ba boetse ba nahana hore ba ka khona ho susumetsa tšebetso ea sepalangoang sa cobalamin-bleomycin ho thusa ho phekola lefuba. lisele tse bonolo haholoanyane. Leha ho le joalo, re ile ra hlokomela hore sena se ka ’na sa se ke sa e-ba bonolo, kaha libaktheria li sebelisa mekhoa e atlehang ea ho thibela lithibela-mafu li sa kenelle.”
Ho etsa sena, bo-rasaense ba ntse ba hlahloba hore na sepalangoang se sebetsa joang.Khopolo-taba ea hona joale ke hore "ka hare ho sele, likhoele tsa likhohola li ntšoa ka ho tlama le ho kenya ATP ka hydrolyzing. Empa ha re tsebe hore na e buleha joang ka ntle ho kenya limolek’hule tse ncha.”
Lipalangoang tsa Dimeric li na le lihalofo tse peli. Tsena li bonahala li hlahella ka ntle ho lera la sele, 'me ho ka etsahala hore li bulehe ka tsela e itseng, joalo ka lemati, ho lumella thepa e ncha ho kena ka seleng.Bo-rasaense ba ne ba batla ho bona hore na ba ka khona. ka tsela e itseng e hlohlelletsa mokhoa ona oa ho bula kapa oa ho lokoloha, kahoo o eketsa ho kena ha lithibela-mafu.
Litlhahiso: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, le DJ Slotboom: Mycobacterial ABC transporters mediate uptake of hydrophilic compounds.Nature, March 26, 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Tags: lithibela-mafu, B lisele, baktheria, lisele, karohano ea lisele, lera la lisele, dieleketerone, electron microscopy, genetics, laboratori, lysosomes, membranes, metabolism, microscopy, molecules, peptides, physiology, proteins, mala, T lisele, lefuba, vithamine B12, vithamine
Dr. Liji Thomas ke Ngaka ea Bongaka le Gynaecologist ea ileng a fumana mangolo ho Government Medical College, Calicut University, Kerala ka 2001.Liji o sebelitse e le moeletsi oa nako e tletseng litabeng tsa ho beleha le mafu a basali sepetleleng sa poraefete ka lilemo tse 'maloa ka mor'a ho fumana mangolo. O buisane le bakuli ba makholo ba tobaneng le mathata a amanang le bokhachane le ho hloka thari, 'me o hlokometse pelehi e fetang 2,000, a lula a loanela ho pepa ho tloaelehileng ho e-na le ho buuoa.
Thomas, Li Ji.(24 March 2020).Bo-rasaense ba fumane hore baktheria ea lefuba e tsamaisa livithamine ka liseleng.News – Medical.Retrieved 18 May 2022 from https://www.news-medical.net/news/20200324/Scientists-discover -tuberculosis-bacteria-channels-vitamins-in-the-cell.aspx.
Thomas, Li Ji."Bo-rasaense ba sibolla hore libaktheria tsa lefuba li tsamaisa livithamine ho li isa liseleng".News - Medical.May 18, 2022..
Thomas, Li Ji.” Bo-rasaense ba sibolla hore libaktheria tsa lefuba li tsamaisa livithamine ka liseleng”.News – Medical.https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into -the-cell.aspx.(E fumanehe ka la 18 Mphalane 2022).
Thomas, Li Ji.2020. Bo-rasaense ba sibolla lefuba la Mycobacterium le fetisetsa livithamine liseleng.News-Medical, e shebiloe ka la 18 Motšeanong 2022, https://www.news-medical.net/news/20200324/Scientists-discover-tuberculosis-bacterium-channels-vitamins-into-the -sele.aspx.
Puisanong ena, re buisana le Dr. Damini Dey oa Cedars-Sinai Medical Center mabapi le lipatlisiso tsa bona tsa morao-rao mabapi le ho sebelisa AI ho bolela esale pele tlhaselo ea pelo.
Puisanong ena, News-Medical e buisana le Dr. Laurence Orbuch mabapi le ho hloka kutloisiso ka lebaka la maemo a gynecological joaloka endometriosis le mokhoa oa ho fetola seo.
Puisanong ena, re qoqa le Ofisiri e ka Sehloohong ea Bongaka ea CMR Surgical, Mark Slack, mabapi le roboto ea bona ea moloko o latelang oa ho buoa, Versius.
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Nako ea poso: May-18-2022
