Timagwiritsa ntchito makeke kuti tikulitse luso lanu.Mukapitiliza kusakatula tsamba ili mukuvomera kugwiritsa ntchito makeke.Zambiri.
Kafukufuku watsopano yemwe adasindikizidwa mu nyuzipepala ya Nature mu Marichi 2020 adanenanso za puloteni yapadera yonyamula yomwe imapezeka mu bakiteriya Mycobacterium tuberculosis. Mosiyana ndi zonyamula zina, puloteni yayikuluyi ya transmembrane vesicle imathandizira kunyamula mamolekyu a hydrophilic, makamaka vitamini B12 kapena cobalamin, kudutsa ma cell membranes.
Kafukufukuyu amachokera ku kugwiritsa ntchito ma microscopy a cryo-electron kuti apeze zithunzi za transporters.Chifuwa cha TB ndi chamoyo chonse chifukwa chili ndi makina onse ofunikira a chibadwa kuti apange cobalamin m'maselo ake.Komabe, ayenera kulandira mavitamini kuchokera kunja kuti apambane bwino.
Kuti akwaniritse izi, amagwiritsa ntchito vitamini B12 transporter, mmodzi wa banja lalikulu la ATP-binding cassette (ABC) transporters. kunyamula ma peptides monga bleomycin, omwe amalepheretsa kukula kwa tizilombo toyambitsa matenda.Ichi ndi chodabwitsa, akutero wofufuza Dirk Slotboom, yemwe amati mamolekyu awiri osiyana kwambiri sanyamulidwa kawirikawiri ndi chotengera chimodzi.
Izi zidapangitsa kuti kafukufuku wapano afufuze kapangidwe ka puloteni yapaderayi. ”'Inali njira yayitali, koma tidamaliza kuiphwanyira pogwiritsa ntchito maikroskopi ya cryo-electron,'” adatero Slotboom. Zotsatira zake zinali zochititsa chidwi: Puloteniyo inali ndi zomwe zingatchulidwe kuti ndi zazikulu, dzenje lalikulu lodzaza ndi madzi omwe amapitilira mu cell membrane M'lifupi mwake, mphamvu yake ndi 7,700 cubic angstroms - mamolekyu asanu ndi awiri a cobalamin, malinga ndi ofufuza. .
Ntchito yonyamula katunduyo ikuwoneka ngati yosavuta: ingodzikhuthula ndikuyika zonse m'madzi. Chifukwa chake fanizo la sluice. Izi zitha kukhala momwe zimatengera mavitamini ndi ma peptides opha maantibayotiki nthawi imodzi, ngakhale mawonekedwe awo ndi osiyana kwambiri.
Kuthekera kopanda kusankha kosasankhidwa kumakhalanso ndi zovuta zake, zomwe zikuwonekeratu kuti ndizosakwanira. 24 maola.
Ofufuzawo adadabwa ndi kusiyana pakati pa chotengera ichi ndi china chilichonse chodziwika chodziwika bwino. Pali umboni wamphamvu wakuti mabakiteriya ena ali ndi machitidwe ofanana, kutanthauza kuti amatenga mamolekyu mwachisawawa kuchokera ku chilengedwe.
Kumbali inayi, ofufuza amachita chidwi ndi kuthekera kwakuti maselo aumunthu angakhalenso ndi njira zofanana kwambiri zonyamulira zinthu monga cobalamin.Vitaminiyi poyamba imamangiriza ku peptide yapamimba yotchedwa intrinsic factor.Peptide iyi imachokera ku maselo apadera a parietal m'mimba. ndipo amalola vitamini B12 kupanga zovuta nazo.Zovutazo zimatengedwa ndi maselo a epithelial.
Zovutazi pamapeto pake zimakhazikika mu lysosomes mkati mwa maselo a epithelial.Lysosomes ndi "matumba odzipha" odzaza ndi michere yamphamvu.Pano, chinthu chamkati chimasweka ndipo B12 imatulutsidwa kuchokera ku lysosome kupita ku selo. . "Ndikukayikira kwambiri kuti chonyamulira chofananira chomwechi chikukhudzidwa," adatero Slotboom.
Asayansi akuganizanso kuti akhoza kulimbikitsa ntchito ya cobalamin-bleomycin transporter kuti athandize kuchiza chifuwa chachikulu. maselo mosavuta. Komabe, tidazindikira kuti izi sizingakhale zophweka, chifukwa mabakiteriya amagwiritsa ntchito njira zothandiza kuti maantibayotiki asalowe. ”
Kuti achite izi, asayansi akufufuza momwe chotengeracho chimagwirira ntchito. Lingaliro lamakono ndiloti "mkati mwa selo, madzi otsekemera amachotsedwa ndi kumanga ndi hydrolyzing ATP. Koma sitikudziwa kuti amatsegula bwanji kunja kuti alowetse mamolekyu atsopano.”
Zotengera za Dimeric zimakhala ndi ma halves awiri. Izi zimawoneka kuti zimatuluka kunja kwa nembanemba ya selo, ndipo n'zotheka kuti zimatsegula mwanjira ina, monga chitseko, kulola katundu watsopano kulowa mu selo.Asayansi ankafuna kuona ngati angathe penapake yambitsani kutsegula kapena kumasuka uku, potero kuonjezera kulowa kwa maantibayotiki.
Zolozera: S. Rempel, C. Gati, M. Nijland, C. Thangaratnarajah, A. Karyolaimos, JW de Gier, A. Guskov, ndi DJ Slotboom: Mycobacterial ABC transporters mediate uptake of hydrophilic compounds.Nature, March 26, 2020 , http://dx.doi.org/10.1038/s41586-020-2072-8
Tags: maantibayotiki, ma cell a B, mabakiteriya, ma cell, magawo a cell, nembanemba zama cell, ma elekitironi, ma electron microscopy, genetics, labotale, lysosomes, nembanemba, kagayidwe kake, microscopy, mamolekyu, peptides, physiology, mapuloteni, m'mimba, T cell, chifuwa chachikulu, vitamini B12, vitamini
Dr. Liji Thomas ndi Dokotala wa Obstetrician ndi Gynecologist yemwe anamaliza maphunziro awo ku Government Medical College, Calicut University, Kerala mu 2001.Liji adagwira ntchito ngati mlangizi wanthawi zonse pazachikazi ndi amayi pachipatala chapadera kwa zaka zingapo atamaliza maphunziro awo. Wakambirana ndi mazana a odwala omwe akukumana ndi mavuto okhudzana ndi mimba komanso kusabereka, ndipo amayang'anira kubereka kopitilira 2,000, nthawi zonse amayesetsa kuti abereke bwino osati opaleshoni.
Thomas, Li Ji.(24 Marichi 2020).Asayansi apeza kuti mabakiteriya a chifuwa chachikulu amanyamula mavitamini kupita ku maselo.News - Medical.Retrieved 18 May 2022 from https://www.news-medical.net/news/20200324/Scientists-discover -TB-bacterium-channels-vitamins-in-the-cell.aspx.
Thomas, Li Ji."Asayansi apeza kuti mabakiteriya a chifuwa chachikulu amanyamula mavitamini kulowa m'maselo".News - Medical.May 18, 2022..
Thomas, Li Ji."Asayansi apeza kuti mabakiteriya a chifuwa chachikulu amanyamula mavitamini kulowa m'maselo" News - Medical. -the-cell.aspx.(Idafikira pa 18 Meyi 2022).
Thomas, Li Ji.2020. Asayansi atulukira kuti Mycobacterium tuberculosis imanyamula mavitamini kupita ku maselo -selo.aspx.
M'mafunsowa, timayankhula ndi Dr. Damini Dey wa Cedars-Sinai Medical Center ponena za kafukufuku wawo waposachedwa wogwiritsa ntchito AI kulosera za matenda a mtima.
M'mafunsowa, News-Medical ikulankhula ndi Dr. Laurence Orbuch za kusamvetsetsa zomwe zimayambitsa matenda achikazi monga endometriosis ndi momwe angasinthire.
M'mafunsowa, timacheza ndi Chief Medical Officer wa CMR Surgical, Mark Slack, za loboti yawo yam'badwo wotsatira, Versius.
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Nthawi yotumiza: May-18-2022
