Kea leboha ka ketelo ea hau /, u sebelisa tšehetso ea mofuta oa sebatli bakeng sa CSS co., LTD. Bakeng sa boiphihlelo bo botle ka ho fetisisa, re khothaletsa hore o sebelise sebatli se secha (kapa o tima mokhoa oa ho lumellana ho Internet Explorer). Khabareng, ho netefatsa ts'ehetso e tsoelang pele, re tla bonts'a sebaka sena ntle le mekhoa le JavaScript.
Mekhoa e lumellang in situ dosimetry le ho netefatsa mefuta e mengata e bohlokoa ho radiotherapy ho fokotsa moeli oa polokeho e hlokahalang ho ela hloko ho se tsitse ho hlahisoang nakong eohle ea ts'ebetso ea kalafo. Boithuto bona bo fana ka mohopolo oa lethal dose o sa hlaseleng bakeng sa radiotherapy ea carbon ion e ipapisitseng le phetoho ea karolo ea ultrasound ea phapang. Li-nanodroplets tse nang le ente tse entsoeng ka metastable perfluorobutane (PFB) cores tse tsitsitseng ka likhetla tsa joala tsa polyvinyl tse kopantsoeng tse fetohang mouoane ka mocheso oa 'mele ha li pepesetsoa mahlaseli a carbon ion (C-ion), li li fetola li-microbubble tsa echo. Li-nanodroplets tse kentsoeng mofuteng oa ho etsisa lithane li ile tsa pepesetsoa ion ea 312MeV/U ea kliniki ka tekanyo ea 0.1-4Gy le mocheso oa mahlaseli oa 37 ℃. Ka ho lekola litšoantšo tsa ultrasound tsa mokhoa oa bongata le ntlafatso ea phapang pele le ka mor'a mahlaseli, ho ile ha fumaneha hore mahlaseli a bohlokoa a bakoang ke mahlaseli a nanodroplet tlhōrōng ea Cion Bragg e ne e le submillimeter displacement reproducible le e itšetlehileng ka tekanyo. Ka ho fetola boemo ba mohlala, marang-rang le ho hasanya tlhōrō ea Bragg, karabo e tobileng ea nanodroplet ho C ion e ile ea tiisoa ka ho eketsehileng. Karabelo ea nanodroplet ho C ion e angoa ke mahloriso mme e ikemetse ka sekhahla sa lethal dose. Liphuputso tsena tsa pele li bonts'a monyetla oa katleho ea in vivo carbon ion dosimetry le netefatso ea scoping ea polymer-shell PFB nanodroplets.
Radiotherapy e tsoetseng pele e sebelisang maballo a likaroloana tse qosoang haholo joalo ka li-proton le li-ion tsa khabone (C-ion) (tse tsejoang ka hore ke hadronic therapy) e sa tsoa fumaneha setsing sa bongaka 'me e ntse e ntlafatsoa lefatšeng ka bophara ka sepheo sa ho eketsa kalafo ea lihlahala tse hananang le lithethefatsi. Ho feta moo, ho nahanoa hore kalafo ea hadron e molemo ho feta kalafo ea radiation ea setso ho alafa mofetše haufi le litho tse mahlonoko, joalo ka mofetše oa matsoele ka lehlakoreng le letšehali haufi le pelo. Li-photon tse sa rateheng tsa X-ray, likaroloana tse qosoang li hasana ha li ntse li kenella ka har'a lisele le ho boloka matla a mangata ka nako ea limilimithara tse 'maloa ka bophara, ebe li emisa, li lokolla boholo ba matla a tsona ka lerotholi le lengata la distal le tsejoang e le Bragg peaks 3,4,5 . Ka hona, kabo ea lethal dose e fumanoang ka ho sebelisa li-haron e phahame ho feta e fumanoang ke li-photon ka lebaka la mefuta e fokolang le e moqotetsane ea deposition (ke hore, ho fokotseha ho fokolang ka morao) ha li-hadrone 'meleng. Leha li-C ion le li-proton li na le melemo e ts'oanang ea 'mele ho feta X-rays, li-C ion li fapana le li-proton tsa thepa ea radiobiological mme hangata li amahanngoa le ho fosahala le lefu le phahameng kalafong. Cornelius A. Tobias o ile a etsa tlhahiso ea pele ea tšebeliso ea li-ion tsa khabone kalafong ea radiation, a pheha khang ea hore li-ion tse boima li ka sebetsa ho feta li-proton. Phapang e kholo ea kabo ea lethal dose lipakeng tsa mefuta e 'meli ea mahlaseli ke hore C ion e na le mohatla o monyane o arohaneng kantle ho ho bola ha eona. Ntle le moo, ka morao, li-ion tsa C - li tšoauoa ka ho bola ho hoholo ho feta sefate sa proton, se lumellanang haholoanyane le sepheo ka lebaka la tlhoro e nyane haholo ea Bragg, e ba lumellang ho otla bongata ba hlahala ka katleho le ho boloka lisele tse phetseng hantle pele le ho feta. ka mor'a hlahala. Ho feta moo, linear energy transfer (LET), e leng matla a matla a likaroloana tse qosoang tse kenngoeng ka har'a thepa e tsamaisoang ke li-proton tsa mantlha ka bolelele ba yuniti, 7, 8, 9.C ions e etsa hore ho be le bioavailability e kholo (RBE) ho Bragg peak. , 'me e bonts'a katleho e nepahetseng khahlanong le lihlahala tse hanyetsanang le lithethefatsi ho LET boleng ba 150-200 keV / μm10 le 11. Ho phaella moo, tsoelo-pele ea morao tjena e bontšitse hore thepa ea radiobiological ea dense ionized carbon e na le liphello tse eketsehileng tsa phekolo kalafo ea kankere, ho matlafatsa likarabo tsa 'mele le ho itšireletsa mafung. ho fokotsa menyetla ea angiogenesis le metastasis7. Thahasello ea bokhoni ba kliniki ea C ions e bonahetse palo e ntseng e eketseha ea bakuli ba phekoloang lilemong tse mashome a mabeli tse fetileng. Liteko tsa Phase I le II tsa Japane li bonts'itse litholoana tse ts'episang ho bakuli ba nang le mofets'e o tsoetseng pele oa lehae. Liteko tse ling tsa kliniki tsa mohato oa II li sa tsoa etsoa Jeremane ho tiisa liphuputso tsena 12. Leha ho le joalo, ho ea ka Particle Therapy Collaboration Group (PTCOG), palo ea litsi tse sebetsang lefatšeng ka bophara e ntse e lekanyelitsoe ho 12; Haholo-holo Europe (Italy, Jeremane, Austria) le Asia (Chaena le Japane), ha litsi tse 13 li ntse li hahuoa United States le Fora.
Ho fihlela hajoale, e 'ngoe ea liqholotso tse mahlonoko tsa likhetho tsohle tsa kalafo ea likaroloana, ho kenyeletsoa kalafo ea radiation ea C-ion, e bile
Nako ea poso: May-23-2022
