Ua tsaug rau koj tuaj xyuas /, koj siv lub browser version txhawb rau CSS co., LTD. Rau qhov kev paub zoo tshaj plaws, peb xav kom koj siv qhov browser tshiab (lossis tig hom kev sib raug zoo hauv Internet Explorer). Nyob rau lub sijhawm no, txhawm rau ua kom muaj kev txhawb nqa txuas ntxiv, peb yuav tso saib lub vev xaib yam tsis muaj qauv thiab JavaScript.
Cov txheej txheem uas tso cai rau hauv situ dosimetry thiab ntau qhov kev lees paub yog qhov tseem ceeb hauv kev kho hluav taws xob los txo cov npoo ntawm kev nyab xeeb uas yuav tsum tau coj mus rau hauv tus account qhov tsis paub tseeb qhia thoob plaws hauv kev kho mob. Txoj kev tshawb no nthuav tawm lub tswv yim tsis muaj tshuaj tiv thaiv kab mob rau carbon ion radiotherapy raws theem hloov pauv tus neeg saib xyuas qhov sib txawv ntawm ultrasound. Injectable nanodroplets ua los ntawm metastable perfluorobutane (PFB) cores stabilized nrog crosslinked polyvinyl cawv plhaub uas evaporate ntawm lub cev kub thaum raug carbon ion hluav taws xob (C-ion), hloov lawv mus rau hauv ncha microbubbles. Cov nanodroplets embedded nyob rau hauv cov ntaub so ntswg simulation qauv tau raug mus rau ib tug 312MeV / U chaw kho mob C ion beam ntawm ib koob ntawm 0.1-4Gy thiab irradiation kub ntawm 37 ℃. Los ntawm kev ntsuam xyuas cov duab ultrasound ntawm ntau hom thiab qhov sib txawv ua ntej thiab tom qab irradiation, nws tau pom tias qhov tseem ceeb ntawm cov hluav taws xob ua rau vaporization ntawm nanodroplet ntawm C ion Bragg ncov yog submillimeter hloov pauv hloov tau thiab koob tshuaj-dependent. Los ntawm kev hloov tus qauv txoj haujlwm, kab teeb ntau thiab tawg ntawm Bragg ncov, cov lus teb tshwj xeeb ntawm nanodroplet rau C ion tau lees paub ntxiv. Cov lus teb ntawm nanodroplet rau C ion yog cuam tshuam los ntawm concentration thiab yog ywj siab ntawm koob tshuaj. Cov kev tshawb pom thaum ntxov no qhia tau tias muaj peev xwm ua rau muaj kev cuam tshuam hauv vivo carbon ion dosimetry thiab scope validation ntawm polymer-plhaub PFB nanodroplets.
Kev siv hluav taws xob zoo tshaj plaws uas siv cov kab hluav taws xob hnyav hnyav xws li protons thiab carbon ions (C-ions) (hu ua hadronic therapy) tsis ntev los no tau dhau los ua kev kho mob thiab tab tom tsim thoob ntiaj teb nrog lub hom phiaj ntawm kev kho cov qog tshuaj tiv thaiv kab mob. Tsis tas li ntawd, kev kho mob hadron tau xav tias yuav muaj txiaj ntsig zoo dua li kev kho hluav taws xob hauv kev kho mob qog noj ntshav nyob ze ntawm lub cev tseem ceeb, xws li mob qog noj ntshav ntawm lub mis ntawm sab laug ze ntawm lub plawv. Tsis zoo li xoo hluav taws xob photons, cov khoom siv hluav taws xob tsis sib xws tsawg dua thaum lawv nkag mus rau cov ntaub so ntswg thiab khaws lub zog siab tshaj plaws nyob rau lub sijhawm ob peb millimeters dav, tom qab ntawd nres, tso tawm lawv lub zog feem ntau hauv cov tshuaj hauv zos ntse heev hauv cov tshuaj poob qis hu ua Bragg peaks 3,4,5. . Yog li, cov koob tshuaj faib tau los ntawm kev siv hadrons yog qhov zoo tshaj qhov uas tau los ntawm photons vim qhov txwv thiab nqaim deposition ntau yam (piv txwv li txwv lateral diffusion) ntawm hadrons hauv lub cev. Txawm hais tias C ions thiab protons muaj qhov zoo sib xws ntawm lub cev zoo li X-rays, C ions txawv ntawm cov protons hauv cov khoom siv hluav taws xob thiab feem ntau cuam tshuam nrog kev tsis zoo thiab kev tuag siab hauv kev kho mob. Cornelius A. Tobias thawj zaug tau thov kom siv cov pa roj carbon ions hauv kev kho hluav taws xob, sib cav tias cov ions hnyav dua yuav ua tau zoo dua li cov protons. Qhov sib txawv tseem ceeb hauv kev faib tshuaj ntawm ob hom hluav taws xob yog tias C ion muaj qhov sib cais me me sab nraud ntawm nws qhov kev puas tsuaj. Tsis tas li ntawd, tom qab, C - ions yog tus cwj pwm los ntawm kev lwj ntau dua li cov kab hluav taws xob proton, uas yog qhov ua tau raws li lub hom phiaj vim qhov nqaim Bragg ncov, uas tso cai rau lawv tawm tsam cov qog nqaij hlav ntau dua thiab zoo tshaj plaws khaws cov ntaub so ntswg noj qab haus huv ua ntej thiab tom qab lub qog. Tsis tas li ntawd, cov kab hluav taws xob hloov pauv (LET), uas yog lub zog ceev ntawm cov khoom siv uas tau muab tso rau hauv cov khoom uas tau hla los ntawm thawj cov protons ib chav tsev ntev, 7, 8, 9.C ions induce siab tshaj plaws txheeb ze bioavailability (RBE) ntawm Bragg ncov. , thiab ua kom pom qhov ua tau zoo tiv thaiv cov qog noj ntshav ntawm LET qhov tseem ceeb ntawm 150-200 keV / μm10 thiab 11. Tsis tas li ntawd, kev nce qib tsis ntev los no tau pom tias cov khoom siv hluav taws xob ntawm cov pa roj carbon monoxide ntom ntom muaj cov txiaj ntsig kho mob ntxiv hauv kev kho mob qog noj ntshav, txhim kho kev tiv thaiv kab mob thiab txo angiogenesis thiab metastasis muaj peev xwm 7. Qhov kev txaus siab ntawm qhov chaw kho mob muaj peev xwm ntawm C ions tau tshwm sim hauv cov neeg mob uas tau kho ntau dua ob xyoo dhau los. Kev sim theem I thiab II hauv Nyij Pooj tau pom tias muaj txiaj ntsig zoo rau cov neeg mob uas mob qog noj ntshav hauv zos. Cov kev sim tshuaj ntxiv theem II tsis ntev los no tau ua nyob rau hauv lub teb chaws Yelemees kom paub tseeb tias cov kev tshawb pom no 12. Txawm li cas los xij, raws li Particle Therapy Collaboration Group (PTCOG), tus naj npawb ntawm cov chaw ua haujlwm thoob ntiaj teb tseem txwv rau 12; Feem ntau hauv Tebchaws Europe (Ltalis, Lub Tebchaws Yelemees, Austria) thiab Asia (Tuam Tshoj thiab Nyiv), thaum 13 lub chaw tab tom tsim kho hauv Tebchaws Meskas thiab Fabkis.
Txog tam sim no, ib qho ntawm cov teeb meem tseem ceeb tshaj plaws ntawm txhua txoj kev kho kab mob, suav nrog C-ion hluav taws xob kho, tau ua.
Post lub sij hawm: May-23-2022
